Role of CD28 in fatal autoimmune disorder in scurfy mice
نویسندگان
چکیده
منابع مشابه
Role of CD28 in fatal autoimmune disorder in scurfy mice.
Scurfy mice develop CD4 T-cell-mediated lymphoproliferative disease leading to death within 4 weeks of age. The scurfy mutation causes loss of function of the foxp3 gene (foxp3(sf)), which is essential for development and maintenance of naturally occurring regulatory CD4 T cells (nTregs). In humans, mutations of the foxp3 gene cause immune dysregulation, polyendocrinopathy, enteropathy, and X-l...
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15 صفحه اولB cells are critical for autoimmune pathology in Scurfy mice.
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ژورنال
عنوان ژورنال: Blood
سال: 2007
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2006-10-054585